BIOMARKERS OF ATHEROGENESIS AND CLINICAL NEUROLOGICAL CHARACTERISTICS OF THE INTERNAL CAROTY ARTERY

Abdulakhad Khamidov; Farruh Saidvaliev; Maqsudjan Ataniyazov

BIOMARKERS OF ATHEROGENESIS AND CLINICAL NEUROLOGICAL CHARACTERISTICS OF THE INTERNAL CAROTY ARTERY

Authors

Abdulakhad Khamidov Tashkent Medical Academy Department of Medical Psychology and Neurology, Uzbekistan, Tashkent, Farobi street, 2. 100109
Farruh Saidvaliev Tashkent Medical Academy Department of Medical Psychology and Neurology, Uzbekistan, Tashkent, Farobi street, 2. 100109
Maqsudjan Ataniyazov Tashkent Medical Academy Department of Medical Psychology and Neurology, Uzbekistan, Tashkent, Farobi street, 2. 100109

Keywords:

triglyceride, chylomicron, apolipoprotein-A1, atherosclerotic plaque, brachiocephalic arteries, chronic brain ischemia, free cholesterol, phospholipid, lipoprotein

Abstract

Atherosclerosis is a multifactorial and widespread process that underlies the development of cardiovascular and cerebrovascular diseases. Atherosclerotic damage of cerebral vessels is a long-term process that passes through several stages during its development, in particular, the "asymptomatic" stage. Considering that atherosclerotic damage of carotid arteries is widely important in the development of acute cerebrovascular disorders, atherosclerotic damage of internal carotid arteries in patients with asymptomatic stenosis was generally considered as a model of atherosclerosis in brachiocephalic arteries (BSA). In this article, clinical-neurological and dopplerographic indicators of the development of the atherosclerotic process in patients with asymptomatic stenosis of the carotid artery are evaluated.

References

M. M. Asadullaev, F. S. Saidvaliev, F. K. Shermukhamedova, J.K. Rizvonov, N.M. Vakhabova (2012). Evaluation of the multimodal effect of cytoflavin in acute cerebral stroke that developed against the background of metabolic syndrome. Journal of Neurology and Psychiatry. SS Korsakov, 112(10), 24-27.

M.M. Asadullaev, G.S. Rakhimbayeva, N.M. Vakhabova, S.A. Zhangirov, (2021). The frequency of the main neurological symptoms in ischemic stroke among elderly patients. Zbirnik naukovih prats SCIENTIA

M.M. Asadullaev, G.S. Rakhimbayeva, N.M. Vakhabova, Sh.A.Zhangirov, (2021). Pathogenetic mechanism in the development of acute ischemic stroke. Zbirnik naukovikh prats SCIENTIA

N.M. Vakhabova, R. B. Azizova, N. N. Abdullayeva. (2019). Gender characteristics of risk factors and background diseases in different variants of ischemic stroke in elderly and senile people.

N.M. Vakhabova. (2021). The structure of clinical and neurological symptoms in acute cerebral strokes in men and women in the elderly and senile age. Journal of Neurology and Neurosurgical Research 2(3).

N.M. Vakhabova. (2021). The specific effect of hyperhomocysteinemia on the occurrence of ischemic stroke of the brain. Journal of Neurology and Neurosurgical Research. Topical issues of neurology. Bukhara, October 20-21, 2021

M. Ergasheva, & N. Vakhabova, (2019). New gender-influenced stroke study:

Cognitive manifestations in acute ischemic stroke in Uzbekistan. Journal of the

Neurological Sciences, 405, 115.

M. Ergasheva, N. Vakhabova, & G. Rakhimbaeva. (2019). Gender, aging and

background diseases influence on the new neuronosological structure of acute

ischemic stroke in Uzbekistan. Journal of the Neurological Sciences, 405, 115.

N. Tolibova, N. Vakhabova, U. Shirasawa. (2017). Gender differences in stroke

subtypes, severity, risk factors, and outcomes among elderly patients with acute

ischemic stroke among the Uzbek population. CEREBROVASCULAR DISEASES 43

N. Tolibova, & N. Vakhabova. (2017). Gender differences in stroke subtypes, severity, risk factors, and outcomes among elderly patients with acute ischemic stroke in Uzbekistan. Journal of the Neurological Sciences, 381, 377.

N. Tolibova, & N. Vakhabova. (2017). Stroke incidence and association with risk factors in women in Uzbekistan. Journal of the Neurological Sciences, 381, 377.

N. Tolibova, & N. Vakhabova. (2017, January). Homocysteine levels and functional outcome in patients with ischemic stroke in Uzbekistan. In CEREBROVASCULAR DISEASES (Vol. 43). ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND: KARGER

N.V. Vereshchagin. Heterogeneity of stroke: a view from the position of a clinician. Neuropathol Journal.and a psychiatrist.-2003.-No.9-pp.23-26

V.L. Feigin, C.M. Lawes, D.A. Bennett, et al., Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review, Lacent Neurol. 8 (4) (2009) 355-369.

G.W. Petty, R.J. Brown, J.P. Whisnant, et al., Ischemic stroke subtypes:

population-based study of incidence and risk factors, Stroke 30 (12) (1999) 2513-2516.

M. de Weerd, J.P. Greving, A.W. de Jong, et al., Prevalence of asymptomatic carotid artery stenosis according to age and sex: systematic review and metaregression analysis, Stroke 40 (4) (2009) 1105-1113.

V. Thijs, Does surgery have a role in the management of asymptomatic carotid artery stenosis? Yes idol, Nat. Clin. Pract. Neurol. 4 (1) (2008) 2-3.

Benditt, EP, Benditt JM. Evidence for monoclonal origin of human atherosclerotic plaques. Proc. Nat. Acad. Sci. USA 2010;70:1753-1756.

Hahn C, Schwartz MA. Mechanotransduction in vascular physiology and atherogenesis. Nat. Rev. Mol. Cell Biol. 2009;10: 53-62

Woolard KJ, Geissmann F. Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol. 2010;7(2): 77–86.

BIOMARKERS OF ATHEROGENESIS AND CLINICAL NEUROLOGICAL CHARACTERISTICS OF THE INTERNAL CAROTY ARTERY