CLINICAL FEATURES OF SJOGREN’S SYNDROME ASSOCIATED WITH VASCULITIS
Keywords:
Sjögren’s syndrome; autoimmune disease; xerophthalmia; xerostomia; hemorrhagic vasculitis; biological therapy; Rituximab; immunological markers; clinical follow-up.Abstract
This article presents the clinical course, diagnostic findings, and treatment process of a 29-year-old female patient with primary Sjögren’s syndrome. The patient’s complaints included dry mouth and eyes, multiple dental caries, joint pain, fatigue, purpuric skin rashes, and vaginal dryness — symptoms characteristic of this autoimmune disorder. Laboratory investigations revealed elevated inflammatory markers, positive rheumatoid factor, and the presence of hemorrhagic vasculitis. Due to insufficient response to standard therapy (prednisolone and hydroxychloroquine), the patient was initiated on biological treatment with Rituximab. This article analyzes the patient’s clinical response to therapy, potential complications, and follow-up dynamics.
References
Kasper D.L., Fauci A.S., Hauser S.L., et al. Harrison’s Principles of Internal Medicine. 20th ed. New York: McGraw-Hill; 2018.
Mukhsimova N.R.,Sh.A. Shiranova Efficiency of complex treatment of patients with psoriatic arthritis against the background of non-alcoholic fatty liver disease/ // Republican Scientific and Practical Center for Sports Medicine. - Tashkent, 2024. - No. 1-94-98-s.
Tan E.M., Smolen J.S. Autoantibodies in Rheumatic Diseases. Arthritis & Rheumatology. 2016;68(2):283–293.
American College of Rheumatology (ACR). Rheumatoid Arthritis Clinical Practice Guidelines, 2021.
Petrova G.V., Sokolova M.A. Clinical Rheumatology. Moscow: GEOTAR-Media; 2020.
Abdullaev A., Kholmuradov B. Propaedeutics of Internal Diseases. Tashkent: TMA Publishing House; 2019.
Nadirshoyev M., Usmonov A. Laboratory diagnostics in autoimmune diseases. Journal of Medicine of Uzbekistan. 2022;4(3):45–52.
World Health Organization (WHO). Laboratory testing for autoimmune diseases. Geneva; 2020.
Vladimirova O.N., Mironova T.A. Rheumatoid factor and its clinical significance. Clinical Laboratory Diagnostics. 2019;64(7):412–418.
Jo‘rayev Sh., Rakhimov F. Autoantibodies: RF and Anti-CCP markers. Scientific Bulletin of Tashkent Medical Academy. 2021;2:77–84.
